In distinction to investigations describing the pro-angiogenic effect of MSCs (Zhang et al., 2013; Li et al., 2016), the anti-tumor activity of MSCs by using inhibition of tumor angiogenesis has also been documented. A examine reported that bone marrow MSCs restrict vascular growth in ΔGli36 glioma xenograft through downregulation on the PDGF/PDGF
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